Donald P. Satchell, Ph.D.

Author

Donald P. Satchell, Ph.D.

Donald P. Satchell, Ph.D., is the founder and owner of Situ Biosciences, where he leads work in antimicrobial performance, biodegradation, toxicology, product durability, and industrial microbiology. His career spans more than 25 years of research, product development, and laboratory leadership, including roles at Microban International and The Dow Chemical Company. He earned his B.S., M.S., and Ph.D. in Biochemistry from the University of California, Riverside.

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Background & Credentials

Professional Profile

Professional Experience

Owner; Situ Biosciences LLC; 2009 to present

  • Industrial Biochemical and Microbiology Specialists for toxicology, antimicrobial, and biodegradable products and applications.
  • Antimicrobial performance testing (ASTM, AATCC, JIS, ISO, NSF, EPA, OECD)
  • Product durability testing
  • Formulation development and design for antimicrobial products for industrial and consumer product applications
  • Biodegradation and product biodegradability assessment and certification.
  • Biochemical and enzyme based technology development

International Director of Technology, Microban Intl., Huntersville, NC, February 2006 to 2009

  • Global new product development and implementation in consumer products.
  • UK Project for NHS hospital new technology trial of antimicrobial products used to reduce hospital surface bacterial counts.
  • Liquid coatings development, applications for antimicrobial applications in NHS hospitals and Nursing homes.
  • Dystar Global Auxiliaries for Textile formulation and application development, in EU, Asia, US and South America.
  • Global hygiene products with Whirlpool EU and US durable products division.
  • New antimicrobial applications thermoset polymer technology development for textiles with Cognis Germany and Turkey.
  • Cosentino Spain antimicrobial polyester resin systems and new supply sourcing and application development.

Sr. Research Biochemist, The Dow Chemical Company, Buffalo Grove, IL, Aug 2002 to 2006

  • North American Technical Leader for Biocides Business Direct Customer and Distributor support and biocide application development for: Medical Devices, Coatings, Disinfectants, Personal Care Products, and Biosecurity.
  • Developed a high-throughput robotic workstation to successfully identify novel antimicrobial agents used as target molecule for new antimicrobial business development. Developed and implemented global business rollout for “TauNovate” a new high-throughput technology
  • Project management for high level disinfectant US FDA 510K approval and global regulatory oversight, patent technology licensing and brand licensing.
  • Laboratory Manager Dow biocides laboratory providing product testing and new application development for industrial preservation, and disinfection for all industrial market segments. New technology development for liquid formulation sanitizers and disinfectants used in formulation development for Clorox 409 (clear).
  • Dow Chemical Cramer Award for Innovation in Developing and Commercializing New Technology
  • Dow Chemical Future Leader Award, Laboratory Innovation and Global Implementation.
  • Dow Chemical, Industrial Chemicals Excellence Recognition (ICE) Award, For Six Sigma Black Belt Certification, High-throughput Technology Development
  • Dow Chemical ICE Award, New Molecule Discovery, Development of Natural Antimicrobials

Postdoctoral Research Associate University of California Irvine Department of Medical Microbiology; 1998 – 2002;

  • Focused at isolating and developing natural antimicrobials found in animal cells. Amino-acid modification and development of test methods to determine mechanisms action and isolation of new functional molecules.
  • National Institute of Health, National Research Service Award Post-Doctoral Fellowship
  • Keystone Immunology Symposium Scholarship Award
  • FASEB Post-doctoral Scholarship Award

Doctoral Research Associate in Biochemistry, University of California, Riverside 1994-1998

  • Recombinant protein expression and biochemical analysis of steroid hormones and natural biological protectants.
  • Identified a unique mechanism for steroid hormone and organic molecule metabolism - 2 publications

Masters Research Associate in Biochemistry, University of California, Riverside 1992-1994

  • In vivo pharmacokinetic analysis of steroid hormone analogs - 2 publications

Technical Expertise

  • Coatings, thermoplastic, and thermoset polymers; application design and formulation development for applications in food, consumer and health industries
  • Industrial assay development and validation of industrially standardized assay methods Microbiology associated with high level disinfectants, biofilm formation and industrial fouling
  • Liquid formulation development for biological and antimicrobial performance attributes
  • Protein and small molecule purification and characterization via liquid chromatography systems
  • High-throughput automation and computer software integration
  • Bioassays for in vivo and in vitro pharmacokinetic studies
  • Biochemical and biophysical analysis of microorganism antimicrobial systems
  • Extensive biophysical techniques using spectrophotometry (CD, UV, FRET), mass spectrometry (QTOF, MALDI, and MS/MS methods), and surface plasmon resonance (BiaCore)
  • Microscopy using epifluorescence, immunofluorescence, confocal, and phase contrast methods.
  • Extensive computer programming and application development for data management and analysis

Education

University of California, Riverside

  • Ph.D. Biochemistry, 1998
  • M.S. Biochemistry, 1994
  • B.S. Biochemistry, 1992 Cum Laude
Publications 19 items
  1. Quantifying Adenosine Triphosphate (ATP) in Water-miscible Metalworking Fluids - ASTM E 2694 Interlaboratory Study to Determine Test Method’s Precision F. Passman, Biodeterioration Control Associates, Inc., Princeton, NJ, P. Whalen, LuminUltra Technologies, Ltd, Fredericton, NB, Canada, D. Satchell, Situ Biosciences, LLC, Skokie, IL
  2. Inside Fashion; April 2011; Understanding Antimicrobials; Battling Bacteria.
  3. Inside Edition; Microbial Contamination of your Jeans; televised editorial on contamination of personal apperal; Feb, 2011.
  4. Lubes‘N’Greases Magazine – State of the Art Microbial Control; accepted to be published; www.lngpublishing.com/index.cfm; June 2010
  5. Citation AATCC; Antimicrobials – Heros in the war against tiny Invaders. Vol 9:5, May 2009;
  6. Patent: Antimicrobial Sealing Element WO/2009/100164; I. Ong and Donald P Satchell; Microban Products Company US.
  7. Satchell, DP; Chemical Sterilants and High-Level Disinfectants: Managing Practical, Safe and Effective Use; Managing Infection Control; June (2006).
  8. Satchell, DP; Sheynis T; Shirafuji Y; Kolusheva S; Ouellette AJ; Jelinek R.: Interactions of mouse Paneth cell alpha-defensins and alpha-defensin precursors with membranes. Prosegment inhibition of peptide association with biomimetic membranes. J. Biol. Chem. 278(16):13838-46 (2003).
  9. Satchell, DP; Sheynis, T; Kolusheva, S; Cummings, J; Vanderlick, TK; Jelinek, R; Selsted, ME; Ouellette, AJ: Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides 24: 1795-1805 (2003).
  10. Cummings, JE.; Satchell, DP; Shirafuji, Y; Ouellette, AJ; Vanderlick, TK. Electrostatically Controlled Interactions of Mouse Paneth Cell alpha-Defensins with Phospholipid Membranes. Australian Journal of Chemistry 56(10), 1031-1034 (2003).
  11. Shirafuji Y; Tanabe H; Satchell DP; Henschen-Edman A; Wilson CL; Ouellette AJ. Structural determinants of procryptdin recognition and cleavage by matrix metalloproteinase-7. J. Biol. Chem. 278:7910-7919 (2003).
  12. Satchell, DP; Ayabe, T; (co-first author); Pesendorfer, P; Tanabe, H; Wilson, CL; Hagen, SJ; Ouellette, AJ: Activation of Paneth cell α-defensins in mouse small intestine. J. Biol. Chem. 277: 5219-5228 (2002).
  13. Ayabe, T; Satchell, DP; Wilson, CL; Parks, WC; Selsted, ME; Ouellette, AJ: Secretion of microbicidal α-defensins by intestinal Paneth cells in response to bacteria. Nature Immunology 1: 113-118 (2000).
  14. Ouellette, AJ; Satchell, DP; Hsieh, MM; Hagen, SJ; Selsted ME: Characterization of luminal Paneth cell α-defensins in mouse small intestine: attenuated antimicrobial activities of peptides with truncated amino termini. J. Biol. Chem. 275: 33969-33973 (2000).
  15. Wilson, CL; Ouellette, AJ; Satchell, DP; Ayabe, T; Lopez-Boado, YS; Stratman, JL; Hultgren, SJ; Matrisian, LM; Parks, WC: Regulation of intestinal α-defensin activation by the metalloproteinase matrilysin in innate host defense. Science 286: 113-17 (1999).
  16. Satchell, DP; Norman, AW: Recombinant expression of the rat vitamin D binding protein. In: A.W. Norman, R. Boullion, M. Thomasset (Eds.) Vitamin D Chemistry, Biology and Clinical Applications of the Steroid Hormone, University of California, Riverside (1997).
  17. Satchell, DP; Norman, AW: Metabolism of the cell differentiating agent 1α,25(OH)2-16-ene-23-yne vitamin D3 by leukemic cells. J. Steroid Biochem. Mol. Biol. 57: 117-24 (1996).
  18. Norman, AW; Bishop, JE; Collins, ED; Seo, EG; Satchell, DP; Dormanen, MC; Zanello, SB; Farach-Carson, MC; Bouillon, R; Okamura, WH: Differing shapes of 1α,25-dihydroxyvitamin D3 function as ligands for the D-binding protein, nuclear receptor and membrane receptor. J. Steroid Biochem. Molec. Biol. 56: 13-22 (1996).
  19. Satchell, DP; Norman, AW: Metabolism of the 1α,25(OH)2D3 analog 1α,25(OH)2-16-ene-23-yne-D3 in BALB/c leukemic mice and WEHI-3 myeloid leukemia cells. In: A.W. Norman, R. Bouillon and M. Thomasset (Eds.) Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Application, Walter de Gruyter, Berlin (1994).
Symposia & Presentations 18 items
  1. MetalCon; Preventing Failures in Roofing and Wall Systems: Evaluating Antimicrobial Performance in Building Materials. October 2026
  2. AATCC International Summit; Antimicrobial Textile Testing, Maximizing Precision and Performance with Certified Reference Materials and Appropriate Antimicrobial Additives. October 2026
  3. CTT Coatings, Trends and Technologies; Sustainability and Antimicrobial Performance: A Technical Strategy for Laboratory- Scale Testing, September 2026
  4. AMI Agricultural Film and Plastics; Anaerobic Biodegradation vs Compostability in Agricultural Plastics: Aligning Claims with Real-World Disposal, July 2026
  5. IFAI Expo Advanced Textiles; Maximizing Precision and Performance: ISO 17034 Certified Antimicrobial Controls for Textile Testing, October 2023
  6. IFAI Expo Advanced Textiles; Enhanced Product Performance and Durability by the Addition of Appropriate Antimicrobials, August 2017
  7. STLE Formulation Challenges and Performance Testing for Environmentally Acceptable Lubricants; November 2016
  8. United States Compost Council; Compostable Product Strategy; Product Claims to Laboratory Testing; February 2016
  9. Coating Trends and Technology; Sustainability and Antimicrobial Performance - Technical strategy for laboratory scale testing of durable antimicrobial coating performance; August 2015
  10. Specialty Papers; Specialty Paper and Sustainability - Technical Strategy for Laboratory Scale Testing of Compostable and Biodegradable Products, August 2015
  11. American Society of Microbiology; Paints and Coatings, preservation, durability and Informative Test Methods; San Diego, CA May 2010.
  12. Dystar Global Conference; Incorporation of antimicrobial into natural and synthetic fibers. Germany, Thailand, US, (2008)
  13. Antimicrobial Peptide Products for Biological Agent Destruction. Defense Threat Reduction Agency, Washington DC, Sept. (2004).
  14. TauNovation, Dow’s High-throughput Technology for the Paint and Coatings Industry. Federal Society for Coatings Technology, International Coating Expo., Chicago, IL, Oct. (2004).
  15. TauNovation, Dow’s High-throughput Technology for the Paint and Coatings Industry. Southern Society for Coatings Technology, Orlando, FL, May (2003).
  16. High-throughput Technology and Capabilities, Dow Cooperate Headquarters, Sherwin-Williams Science and Technology Exploration Day, Midland, MI, Feb. (2003).
  17. Processing and Activation of α-Defensins in Mouse Small Intestinal Paneth Cells. Keystone Symposia on Mucosal Immunity, Breckenridge, Colorado, Apr. (2002).
  18. Amino Acid Determinants of Microbicidal Activity for Cryptdin-4: a Mouse Paneth Cell α-Defensin. 3rd Gordon Research Conference on Antimicrobial Peptides, Ventura, California, March (2001).

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